I've been fooling with Print Prism for a couple weeks now. Also used to use Profile Prism until it became difficult to get decent IT-8 targets with good data files. IMO, IT-8 isn't good enough anyway. My scanner is LiDE 400, not 300, but it works perfectly. My normal target size is a half sheet, 5.5x 8.5, but you get better results with a full sheet. Very few variable or out-of-range patches. For some reason it's critical to get the target dead-nuts square in the scanner. That's the key to getting just a couple clipped or out of range patches. The latest version of the software automates just about everything, so it's near impossible to make a mistake. Turns out you can still access the scanner settings if you hold Ctrl while clicking on the scan button (per Mike, I haven't tried it).
Visually my results are excellent, with both the Eval print everybody uses, and my own stuff. Some subtle color shifts I've been fighting are gone now. Mike says not to obsess over soft proof gamut warnings and profile volume, but the data geek in me still wonders. If I use ProfileMaker/ProfileEditor 5.0 (gamut view) to compare the 2D and 3D gamut displays using my Prism profiles, my i-One spectro profiles, and Red River factory profiles, the Prism profiles are definitely quite a bit smaller, especially at lower L* values. I need to do more tests, but so far I can't see anything in the prints that suggests any shortcomings in the Prism profiles.
This is certainly fool-proof, faster and way more paper and ink efficient than messing with the spectro.