I don’t reckon you need to worry about the remaining ink in the print head, because when you change the cart the printer will run a substantial cleaning cycles anyway..
Usual cleaning cycles suck about 0.3-0.4ml per color on Pixma printers. (according to Canon's service manuals )
That's enough to clean any residue of the former ink inside non-Maxify printehads.
I don't know if Maxify cleaning cycles waste as much as 2 ml when the user replaces the cart. It seems a huge amount of ink to go into the waste ink pads for no reason at all, because Canon expects that people uses only OEM inks (ahem..). In this ideal condition, no problem if the remaning ink inside the printhead mixes with ink flowing from the new OEM cart.
Of course, bad boys and girls refilling with third party ink, are not taken into consideration in this equation, so if something nasty happens when OEM and non-OEM inks mix, this is our problem.

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Concerning Maxify’s cartridge-printhead system there’s a positive factor, if compared to most Pixmas, because it doesn’t have any kind of sponge, so much less chance of ‘yello-gello’ clogs. The possible issue could happen only on the surface of the mesh filter located at the bottom of the inkflow control chamber. Those filters are of the same kind used at the entry ports of most Canon printheads, only the shape is different.
Of course it’s possible to clog the mesh filter if mixing different inks produces a sort of thick gel that blocks significantly the inkflow, That seems unlikely but I wonder.. the first brand of compatible ink that I used on my Maxify was terrible with recurring clogs.